B lymphocyte stimulator, interferon-α and HMGB 1 interrelation in childhood onset systemic lupus erythematosus: associations with disease activity and severity
نویسندگان
چکیده
Methods 34 cSLE patients (study group), 51 with other rheumatic or autoimmune diseases and 26 healthy children (control groups) were studied. For evaluating the disease activity, SLEDAI and ECLAM scores were used. For estimating the disease severity the criteria were: involvement of 3 vital organs (kidneys or CNS or blood or combination of ≥2 organs), increased anti-dsDNA titres, low C3 /C4 concentrations and high concentrations of serum IFN-a and HMGB1 (High mobility group box 1) protein.
منابع مشابه
Clinical and serological manifestations associated with interferon-α levels in childhood-onset systemic lupus erythematosus
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